• zod000@lemmy.dbzer0.com
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      3 days ago

      I know of several people that were really into whippits that are dead now, but it wasn’t from the whippits. It was from all the other stuff they did in addition to whippits.

      • Warl0k3@lemmy.world
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        21 hours ago

        The short summary is “Yeah, it’s what pretty much anyone would call mostly harmless”.

        The long summary is “It is not completely without risk, especially for those rare people with a complicating factor that leaves them prone to B12 deficiency, but chronic symptoms only come from high risk individuals and chronic heavy exposure”. And the reports of “nitrous psychosis” are pretty much just rumor, from what I know there have been no studies that found you could “go crazy” from nitrous oxide exposure. The recorded neurological effects are minor and reversible in all but the most extreme cases of complicating factors.

        N2O MSDS for anyone curious. Aside from potential respiratory depression from inhalation, there are no side effects listed.

        More recent literature has examined the association with N2O toxicity and B12 deficiency. Long term sustained exposure to high levels of N2O can in some rare circumstances cause B12 deficiency, leading to neuropathy/parathesia and associated neurological phenomena (side note that in all the literature I’ve seen it is treatable).

        It’s also quite uncommon to experience these side effects even with heavy use:

        Findings from a survey conducted by Winstock and Ferris completed by over 16,000 recreational nitrous oxide users suggest that neurologic symptoms may be dose dependent with a 3.5% increase in reports of paresthesia with every 10% increase in nitrous oxide dose used

        Incidentally the only deaths reported from N2O use have been from suffocation. However it’s important to note that clinical and recreational use should be avoided by people with a condition that makes them prone to B12 deficiency:

        It is also important to screen those with an underlying susceptibility to vitamin B12 deficiency for nitrous oxide use, as the clinical manifestations of vitamin B12 deficiency have been noted not only in long-term nitrous oxide users, but also after a single exposure in those with susceptibility to vitamin B12 deficiency.

        • Dozzi92@lemmy.world
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          3 days ago

          Appreciate that long writeup. And a mitigating factor is supplemental vitamin b12. B12 fortunately exists everywhere, but taking either a supplement or something rich in B12 post Nos exposure can help to mitigate the negative effects.

      • Malica@lemmy.zip
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        4 days ago

        Just make sure the room is ventilated because nitrogen is heavier than the air, it will slowly gather and you could suffocate without realizing it.

        • spankysalmon@fedinsfw.app
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          4 days ago

          It can settle in your lungs regardless of how the room is ventilated. Not that most anyone will die from it, but these idiots wouldn’t understand what low oxygen does to a brain even if it were a worm in there instead.

          • Warl0k3@lemmy.world
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            4 days ago

            It does not “settle in your lungs” because that’s not how lungs work at all. You can of course suffocate if the atmosphere is sufficiently saturated with NO2, but your lungs are more than capable of fully expelling water; removing a gas is not difficult.

            Excretion: Nitrous oxide is primarily eliminated via the lungs. (source)

            Nitrous oxide is primarily eliminated through expiration and is essentially not metabolized by the body. (source)

            Seriously, where are you getting your info from?

            • Dozzi92@lemmy.world
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              3 days ago

              Yeah, everything I’m reading in this thread are all the same old wives tales that I remember hearing 15+ years ago all the time. These are DARE facts as far as I’m concerned, and they just propagated.

              • Warl0k3@lemmy.world
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                3 days ago

                Goodness gracious, you mean to imply that the atmosphere is composed almost entirely from N2 and O2? Goodness, now what else can you make from those two atoms… Just can’t quite think of it…

            • tomi000@lemmy.world
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              3 days ago

              Not only confidently incorrect, now youre even insulting. Maybe try learning some actual facts about the stuff you are talking about instead of relying on fearmongering abd being butthurt.

            • Warl0k3@lemmy.world
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              4 days ago

              They are correct - nitrous oxide inhalation does not automatically cause brain damage.

              When inhalation of high concentrations of nitrous oxide is discontinued, high partial pressure in blood transfers nitrous oxide to the alveoli rapidly. This dilutes the partial pressure of oxygen in the alveoli and may lead to hypoxemia. […] This concern is more theoretical than clinical, however. Hypoxemia is significant for only a matter of minutes and has been documented only when high concentrations (>70%) have been delivered by full mask or by endotracheal tube. These conditions cannot be met with the use of conventional dental nitrous oxide machines with nasal masks, and any tendency for diffusion hypoxia is trivial.

              (source)

              (edit: clarity, typo)

              • spankysalmon@fedinsfw.app
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                4 days ago

                Yea, if you do it once. How many dipshits do it once? Besides, I personally know multiple people that have chronic issues from doing it too much.

                Again, your ignorance does not reflect reality. Period.

                • Warl0k3@lemmy.world
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                  4 days ago

                  I’m terribly sorry, but do you happen to have any sources? The literature does not reflect, well, absolutely anything you’re saying.

                  • spankysalmon@fedinsfw.app
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                    4 days ago

                    People do not huff pure lab grade chemicals in the real world. People do not stop when it’s prudent in the real world. The fact you’re defending huffing oxygen-displacing gas is not just weird but exceptionally pathetic.

              • Warl0k3@lemmy.world
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                4 days ago

                No need to hurl slurs over this - besides, it’s not an explanation of their behavior here; by any classic definition I would be considered retarded, and I’m far more informed on this subject than they are.